KW-3049 free base MedChemExpress (MCE)

Product Name	Benidipine
Synonyms	BND CONIEL KW-3049 Benidipine BENIDIPINE NACADIPINE CAPADIPINE Synonyms BND CONIEL KW-3049 Benidipine BENIDIPINE NACADIPINE CAPADIPINE BENIDIPINE HCL (3R)-1-benzylpiperidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R,R)- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel- 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, (4R)-rel- (R,R)-(±)-(3,5-Pyridinedicarboxylic acid 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl 1- (phenylmethyl)-3-piperidinyl ester monohydrochloride
CAS	105979-17-7
EINECS
Chemical Formula	C28H31N3O6
Molecular Weight	505.56
inchi	InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1
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Descriptions	Benidipine Benidipine MedChemExpress (MCE) HY-B1448A 105979-17-7 KW-3049 free base Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Benidipine Benidipine MedChemExpress (MCE) HY-B1448A 105979-17-7 KW-3049 free base Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Benidipine is a potent and orally active calcium channel antagonist. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats. Benidipine (3, 5, 10 µg/kg i.v.) shows significant anti-apoptosis effects in a haemodynamically independent manner[2]. Benidipine (5 mg/kg i.v. every other day for 6 weeks) increases the activity of endothelial cell-type nitric oxide synthase (eNOS) and improves coronary circulation in hypertensive rats[3]. Benidipine (1, 3, 10 mg/kg p.o. once daily for 1 week) significant cardioprotective effects against ischemia-reperfusion injury[4]. \| \| \| \| \| \| \| \| \| \| [1]. Yao K, et al. Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker. J Pharmacol Sci. 2006 Apr 100(4):243-61. [Content Brief] [2]. Gao F, et al. Anti-apoptotic effect of benidipine, a long-lasting vasodilating calcium antagonist, in ischaemic/reperfused myocardial cells. Br J Pharmacol. 2001 Feb 132(4):869-78. [Content Brief] [3]. Kobayashi N, et al. Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats. Am J Hypertens. 1999 May 12(5):483-91. [Content Brief] [4]. Masanori S, et al. Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart. Circ J. 2004 Mar 68(3):241-6. [Content Brief]
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Last Update	2025-05-21 16:50:25

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