SKF-102886 free base; WR-171669 MedChemExpress (MCE)

Product Name	HALOFANTRINE
Synonyms	Halofan WR-171669 SKF-102886 HALOFANTRINE 3-DIBUTYLAMINO-1-(1,3-DICHLORO-6-TRIFLUOROMETHYL-PHENANTHREN-9-YL)-PROPAN-1-OL HCL 9-Phenanthrenemethanol,1,3-dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)- Synonyms Halofan WR-171669 SKF-102886 HALOFANTRINE 3-DIBUTYLAMINO-1-(1,3-DICHLORO-6-TRIFLUOROMETHYL-PHENANTHREN-9-YL)-PROPAN-1-OL HCL 9-Phenanthrenemethanol,1,3-dichloro-a-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)- 9-Phenanthrenemethanol, 1,3-dichloro-.alpha.-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-
CAS	69756-53-2
EINECS	274-104-1
Chemical Formula	C26H30Cl2F3NO
Molecular Weight	500.42
inchi
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Descriptions	Halofantrine Halofantrine MedChemExpress (MCE) HY-A0148 69756-53-2 SKF-102886 free base Descriptions Halofantrine Halofantrine MedChemExpress (MCE) HY-A0148 69756-53-2 SKF-102886 free base WR-171669 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum. Halofantrine blocks HERG potassium channels. Halofantrine blocks HERG tail currents elicited on repolarization to 760 mV from +30 mV with an IC50 of 196.9 nM[2]. Halofantrine inhibits MDA-MB-231 triple-negative breast cancer (TNBC) cell proliferation with the IC50 of 7.73±0.23 μM[3]. Halofantrine exhibits activity against asexual forms (3D7A), asexual forms (3D7HT-GFP), and mature gametocytes IV-V with IC50s of 0.0011, 0.0012, and 6.70 μM, respectively[4]. Plasmodium \| \| \| \| \| \| \| \| \| \| [1]. A J Humberstone, et al. Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum. J Pharm Sci. 1998 Feb 87(2):256-8. [Content Brief] [2]. H Tie, et al. Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br J Pharmacol. 2000 Aug 130(8):1967-75. [Content Brief] [3]. Ji-Hyun Lee, et al. CDA: combinatorial drug discovery using transcriptional response modules. PLoS One. 2012 7(8):e42573. [Content Brief] [4]. Joël Lelièvre, et al. Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay. PLoS One. 2012 7(4):e35019. [Content Brief]
Supplier Website	https://www.medchemexpress.com/halofantrine.html
Last Update	2025-05-21 16:50:25

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