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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product Nameγ-Acetylenic GABA
SynonymsRMI-71645;γ-Acetylenic GABA;Γ-ACETYLENIC GABA;GAMMA-ACETYLENIC GABA;4-amino-5-hexynoicaci;4-Aminohex-5-ynoic acid;4-AMINO-5-HEXYNOIC ACID;5-Hexynoic acid, 4-amino-
CAS57659-38-8
EINECS
Chemical FormulaC6H9NO2
Molecular Weight127.14
inchi
PackageInquiry
PriceGet quote
Descriptionsγ-Acetylenic GABA

γ-Acetylenic GABA

MedChemExpress (MCE)

HY-131693

57659-38-8

GAG

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

γ-Acetylenic GABA

γ-Acetylenic GABA

MedChemExpress (MCE)

HY-131693

57659-38-8

GAG

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain. γ-Acetylenic GABA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

γ-Acetylenic GABA (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2].

GABA-transaminase[1] In Vivo γ-Acetylenic GABA (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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[1]. Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec
37(12):1376-9. [Content Brief]

[2]. Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15
50(4):325-36. [Content Brief]

[3]. Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13
(4):CD000203. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/γ-acetylenic-gaba.html
Last Update2025-05-21 16:50:25
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