CGP 39551 MedChemExpress (MCE)

Product Name	(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYL ESTER
Synonyms
CAS	127910-32-1
EINECS
Chemical Formula	C8H16NO5P
Molecular Weight	237.19
inchi
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Descriptions	CGP 39551 CGP 39551 MedChemExpress (MCE) HY-107703 127910-32-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions CGP 39551 CGP 39551 MedChemExpress (MCE) HY-107703 127910-32-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity. CGP 39551 shows measurable inhibitory activity at both L-[3H]-glutamate (Ki=8.4 μM). CGP 39551 inhibits the binding of the selective NMDA receptor antagonist, [3H]-CPP to rat brain postsynaptic densities (PSDs) with a Ki of 310 nM[2]. CGP 39551 exhibits maximal electroshock-induced seizures in mice with the ED50 of 4 mg/kg (p.o.)[2]. Following chronic neonatal treatment with CGP 39551, adult rats show increased behavioral responses to the D2 dopamine receptor stimulation[3]. \| \| \| \| \| \| \| \| \| \| [1]. G E Fagg,et al. CGP 37849 and CGP 39551: novel competitive N-methyl-D-aspartate receptor antagonists with potent oral anticonvulsant activity. Prog Clin Biol Res. 1990 361:421-7. [Content Brief] [2]. G E Fagg, et al. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. Br J Pharmacol. 1990 Apr 99(4):791-7. [Content Brief] [3]. R Dall'Olio, et al. Chronic neonatal blockade of N-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat. Neuroscience. 1994 Nov 63(2):451-5. [Content Brief]
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Last Update	2025-05-21 16:50:25

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