Hu7691 MedChemExpress (MCE)

Product Name	Hu7691 free base
Synonyms	Hu7691 free base;Benzamide, N-[(3S,4S)-4-(3,4-difluorophenyl)-3-piperidinyl]-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)-
CAS	2241232-43-7
EINECS
Chemical Formula	C22H21F3N4O
Molecular Weight	414.42
inchi
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Descriptions	Hu7691 free base Hu7691 free base MedChemExpress (MCE) HY-132302A 2241232-43-7 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Hu7691 free base Hu7691 free base MedChemExpress (MCE) HY-132302A 2241232-43-7 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice. Hu7691 free base displays low inhibitions against most of the kinases in the four families (AGC, TK, TKL, Lipid/Atypical PKA, IC50=11 nM PKCη, IC50=629 nM ROCK1, IC50=354 nM RSK1, IC50=756 nM P70S6K, IC50=229 nM SGK, IC50=1009 nM)[1]. Hu7691 free base (2.25-36 μM 24 hours) induces effective decrease of the phosphorylation level of Akt (S473)[1]. Hu7691 free base (10, 20, 30, 40 μM for 72 h) exhibits low toxicity against HaCaT cells with an IC50 value of 15.2 μM[1]. Hu7691 free base has a significant inhibitory effect on the growth of 18 kinds of human tumor cells (U87-MG, U251, A549, HepG2, HT-29, KHOS, MDA-MB-231, PC3, SKOV3 and so on) derived from different tissues, with the IC50 range of 0.6-27 μM. Hu7691 free base shows low antiproliferation activities against the HL7702 and HPDE6-C7 normal cells, exhibiting IC50 values of 5.4 and 16.1 μM, respectively[1]. Hu7691 free base (12.5-50 mg/kg/day i.g. for 22 days) shows dose-dependent tumor growth inhibition[1]. Hu7691 free base (15 mg/kg oral) has a T1/2 of 8.68 hours, a Cmax of 171.17 ng/mL and an AUC of 2820.64 ng/mL•h in rats[1]. Hu7691 free base (2 mg/kg iv) has a T1/2 of 6.24 hours, a Cmax of 207.52 ng/mL and an AUC of 532.87 ng/mL•h in rats[1]. Hu7691 free base (20 mg/kg oral) has a T1/2 of 16.7 hours, a Cmax of 905.65 ng/mL and an AUC of 36303 ng/mL•h in beagle dog (male, 40 weeks old, 8–10 kg)[1]. Akt1 4.0 nM (IC50) Akt2 97.5 nM (IC50) Akt3 28 nM (IC50) PKA 11 nM (IC50) PKCη 629 nM (IC50) ROCK1 354 nM (IC50) RSK1 756 nM (IC50) p70S6K 229 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Jinxin Che, et al. Discovery of N-((3 S,4 S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1 H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity. J Med Chem. 2021 Aug 26 64(16):1 [Content Brief]
Supplier Website	https://www.medchemexpress.com/hu7691-free-base.html
Last Update	2025-05-21 16:50:25

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