GSK-J5 MedChemExpress (MCE)

Product Name	QQHQMHJAOKADED-UHFFFAOYSA-N
Synonyms	QQHQMHJAOKADED-UHFFFAOYSA-N;N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine,ethylester,monohydrochoride
CAS	1797983-32-4
EINECS
Chemical Formula	C24H28ClN5O2
Molecular Weight	453.964
inchi
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Descriptions	GSK-J5 hydrochloride GSK-J5 hydrochloride MedChemExpress (MCE) HY-15648H 1797983-32-4 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions GSK-J5 hydrochloride GSK-J5 hydrochloride MedChemExpress (MCE) HY-15648H 1797983-32-4 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. GSK-J5 hydrochloride is a cell-permeable?ester derivative of?GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an?isomer of GSK-J4 (HY-15648B) and often used as a negative group. GSK-J5 (25 μM)?has no effects at inhibiting the LPS-induced response of human primary macrophages derived from healthy volunteers. While GSK-J4 significantly reduced the expression of 16 of 34 LPS-driven cytokines as assessed by PCR array, such as TNF-α[1]. GSK-J5 (30 μM 6 hours) is the inactive isomer of GSK-J4, has no effect on TNF-α protein production. But neither GSK-J4 nor GSK-J5 directly affects the levels of LPS-induced JMJD3 or of LPS-independent UTX and EZH2[1].GSK-J5 (30 μM 1 hour) can not prevent the LPS-induced loss of H3K27me3 associated with the?TNFA?TSS or block the recruitment of RNA polymerase II to this locus but GSK-J5 can. Finally, GSK-J4, but not GSK-J5, blocks the production of TNF-α by macrophages derived from patients with rheumatoid arthritis[1]. \| \| \| \| \| \| \| \| \| \| [1]. Laurens Kruidenier, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16 488(7411):404-8. [Content Brief]
Supplier Website	https://www.medchemexpress.com/gsk-j5-hydrochloride.html
Last Update	2025-05-21 16:50:25

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