UK-80067 MedChemExpress (MCE)

Product Name	Modipafant
Synonyms	Uk 80067;Modipafant;ethyl (4R)-4-(2-chlorophenyl)-6-methyl-2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate
CAS	122957-06-6
EINECS
Chemical Formula	C34H29ClN6O3
Molecular Weight	605.09
inchi
Package	Inquiry
Price	Get quote
Descriptions	Modipafant Modipafant MedChemExpress (MCE) HY-108908A 122957-06-6 UK-80067 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Modipafant Modipafant MedChemExpress (MCE) HY-108908A 122957-06-6 UK-80067 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505. when preincubated with rabbit platelets, the potency of antagonizing PAF induced aggregation increased markedly when preincubation time with Modipafant was increased from 2 min (IC50=5.6 nM) to 60 min (IC50=0.34 nM)[2]. \| \| \| \| \| \| \| \| \| \| [1]. Kuitert LM, et al. Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma. Am J Respir Crit Care Med. 1995 151(5):1331-1335. [Content Brief] [2]. Jezequel SG, et al, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man. Xenobiotica. 1996 26(9):963-975. [Content Brief]
Supplier Website	https://www.medchemexpress.com/modipafant.html
Last Update	2025-05-21 16:50:25

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