D-Cl-amidine MedChemExpress (MCE)

Product Name	D-Cl-amidine
Synonyms	D-Cl-amidine
CAS	1404060-15-6
EINECS
Chemical Formula	C14H19ClN4O2
Molecular Weight	310.78
inchi
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Descriptions	D-Cl-amidine D-Cl-amidine MedChemExpress (MCE) HY-100574C 1404060-15-6 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions D-Cl-amidine D-Cl-amidine MedChemExpress (MCE) HY-100574C 1404060-15-6 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity. D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1]. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1]. D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ～10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1]. \| \| \| \| \| \| \| \| \| \| [1]. Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26 3(12):1081-1085. [Content Brief]
Supplier Website	https://www.medchemexpress.com/d-cl-amidine.html
Last Update	2025-05-21 16:50:25

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