Azido-PEG5-succinimidyl MedChemExpress (MCE)

Product Name	Azido-PEG5-succinimidyl carbonate
Synonyms	Azido-PEG5-succinimidyl carbonate
CAS	1402411-88-4
EINECS
Chemical Formula	C17H28N4O10
Molecular Weight	448.43
inchi
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Descriptions	Azido-PEG5-succinimidyl carbonate Azido-PEG5-succinimidyl carbonate MedChemExpress (MCE) HY-140769 1402411-88-4 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Azido-PEG5-succinimidyl carbonate Azido-PEG5-succinimidyl carbonate MedChemExpress (MCE) HY-140769 1402411-88-4 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Azido-PEG5-succinimidyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-succinimidyl carbonate is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PEGs \| \| \| \| \| \| \| \| \| \| [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct 36:553-562 [Content Brief]
Supplier Website	https://www.medchemexpress.com/azido-peg5-succinimidyl-carbonate.html
Last Update	2025-05-21 16:50:25

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