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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameDibenzofuran, 6-methyl-1,3,8-trichloro-
SynonymsDibenzofuran, 6-methyl-1,3,8-trichloro-
CAS118174-38-2
EINECS
Chemical FormulaC13H7Cl3O
Molecular Weight285.55
inchi
PackageInquiry
PriceGet quote
DescriptionsAhR modulator-1

AhR modulator-1

MedChemExpress (MCE)

HY-135671

118174-38-2

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

AhR modulator-1

AhR modulator-1

MedChemExpress (MCE)

HY-135671

118174-38-2

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus.

AhR modulator-1 (6-MCDF
0.1-10 μM
48-96 hours
ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively[2].

AhR modulator-1 (6-MCDF
0-40 mg/kg
oral administration
daily
for 12 weeks
C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced[1].

Aryl hydrocarbon receptor (AhR) [1][2] Prostatic VEGF[1] Estrogenic[1] In Vitro AhR modulator-1 (6-MCDF
0.1-10 μM
48-96 hours
ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AhR modulator-1 Related Antibodies Cell Proliferation Assay[2] Cell Line: ASPC-1 cells

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[1]. Fritz WA, et al. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol. 2009 Apr 1
77(7):1151-60. [Content Brief]

[2]. Koliopanos A, et al. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Oncogene. 2002 Sep 5
21(39):6059-70. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/ahr-modulator-1.html
Last Update2025-04-01 14:45:47
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