Duocarmycin SA MedChemExpress (MCE)

Product Name	Duocarmycin SA
Synonyms	Duocarmycin SA
CAS	130288-24-3
EINECS
Chemical Formula	C25H23N3O7
Molecular Weight	477.47
inchi
Package	1 mg
Price	Get quote
Descriptions	Duocarmycin SA Duocarmycin SA MedChemExpress (MCE) HY-12456 130288-24-3 99.55% -20°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions Duocarmycin SA Duocarmycin SA MedChemExpress (MCE) HY-12456 130288-24-3 99.55% -20°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro. Duocarmycin SA (DSA) (0.1-1 nM 72 hours) inhibits U-138 cell viability in a dose-dependent manner and activates apoptotic and necrotic pathways[2]. Duocarmycin SA (0.1 nM 72 hours) sensitizes human glioma cells to proton irradiation[2]. Duocarmycin SA (0.143 mg/kg, i.p., single dose) shows antitumor activity in murine lymphocytic leukemia P388 transplanted in CDF1 mice and shows a significant 30% increase in life span[3]. Duocarmycins \| \| \| \| \| \| \| \| \| \| [1]. MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15 19(24):6962-5. [Content Brief] [2]. Boyle KE, et.al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1 28(16):2688-2692. [Content Brief] [3]. Ichimura M,et.al. Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp. J Antibiot (Tokyo). 1990 Aug 43(8):1037-8. [Content Brief]
Supplier Website	https://www.medchemexpress.com/duocarmycin-sa.html
Last Update	2025-05-21 16:50:25

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