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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameTP0463518
SynonymsBGE-117;TP0463518;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-
CAS1558021-37-6
EINECS
Chemical FormulaC20H18ClN3O6
Molecular Weight431.83
inchi
Package10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
PriceGet quote
DescriptionsTP0463518

TP0463518

MedChemExpress (MCE)

HY-112144

1558021-37-6

98.62%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Room temperature in continental US

Descriptions

TP0463518

TP0463518

MedChemExpress (MCE)

HY-112144

1558021-37-6

98.62%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Room temperature in continental US
may vary elsewhere.

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM.

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[1]. Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5
838:138-144. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/TP0463518.html
Last Update2025-05-21 16:50:25
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