GRKs-IN-1 MedChemExpress (MCE)

Product Name	GRK2-IN-1
Synonyms	GRK2-IN-1;CCG258208;Benzamide, 5-[(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-piperidinyl]-2-fluoro-N-(1H-pyrazol-3-ylmethyl)-
CAS	2055990-90-2
EINECS
Chemical Formula	C24H25FN4O4
Molecular Weight	452.48
inchi
Package	Inquiry
Price	Get quote
Descriptions	CCG258208 CCG258208 MedChemExpress (MCE) HY-109562 2055990-90-2 GRKs-IN-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions CCG258208 CCG258208 MedChemExpress (MCE) HY-109562 2055990-90-2 GRKs-IN-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. CCG258208 (GRK2-IN-1) is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 can be used in heart failure research. CCG258208 (Compound 14as) (0-1 μM 10 min) shows significant improvement in βAR-stimulated contractility in mouse cardiomyocytes[1]. CCG258208 (Compound 14as) (intraperitoneal injection 10 mg/kg once) treatment shows superior half-life in vivo[1]. GRK2 30 nM (IC50) GRK5 7.1 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Waldschmidt HV, et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13 60(7):3052-3069. [Content Brief]
Supplier Website	https://www.medchemexpress.com/grk2-in-1.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-05-21 16:50:25

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-05-21 16:50:25

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-05-21 16:50:25

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-05-21 16:50:25

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-05-21 16:50:25

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-05-21 16:50:25

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-05-21 16:50:25

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact