FT-1518 MedChemExpress (MCE)

Product Name	2-Pyrazinamine, 5-[9-(1-ethylpropyl)-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-9H-purin-6-yl]-
Synonyms	2-Pyrazinamine, 5-[9-(1-ethylpropyl)-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-9H-purin-6-yl]-;FT-1518;FT 1518,FT1518;5-[2-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)-9-pentan-3-ylpurin-6-yl]pyrazin-2-amine
CAS	1313026-58-2
EINECS
Chemical Formula	C20H26N8O
Molecular Weight	394.47
inchi
Package	5 mg;10 mg;25 mg
Price	Get quote
Descriptions	FT-1518 FT-1518 MedChemExpress (MCE) HY-107363 1313026-58-2 98.62% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions FT-1518 FT-1518 MedChemExpress (MCE) HY-107363 1313026-58-2 98.62% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1]. FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1]. mTORC1 mTORC2 \| \| \| \| \| \| \| \| \| \| [1]. Alain C. Mita, et al. Abstract 137: FT-1518, a new generation selective and potent mTORC1 and mTORC2 inhibitor: an in vitro and in vivo profile. Cancer Res 2017 77(13 Suppl).
Supplier Website	https://www.medchemexpress.com/FT-1518.html
Last Update	2025-05-21 16:50:25

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