DS-3201 MedChemExpress (MCE)

Product Name	DS-3201
Synonyms	DS-3201 Valemetostat (R)-7-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-((1r,4R)-4-(dimethylamino)cyclohexyl)-2,4-dimethylbenzo[d][1,3]dioxole-5-carboxamide 1,3-Benzodioxole-5-carboxamide, 7-chloro-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-2-[trans-4-(dimethylamino)cyclohexyl]-2,4-dimethyl-, (2R)-
CAS	1809336-39-7
EINECS
Chemical Formula	C26H34ClN3O4
Molecular Weight	488.02
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Get quote
Descriptions	Valemetostat Valemetostat MedChemExpress (MCE) HY-109108 1809336-39-7 DS-3201 99.68% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Valemetostat Valemetostat MedChemExpress (MCE) HY-109108 1809336-39-7 DS-3201 99.68% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Valemetostat (DS-3201), a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat can be used for the research of relapsed/refractory peripheral T-cell lymphoma. Valemetostat (1-1000 nM) strongly and specifically inhibits EZH1 and EZH2 with IC50 values ＜10 nM[3]. Valemetostat (100 nM 7 d) effectively removes H3K27me3 and also prevents unexpected gain of H3K27me3[3]. Valemetostat (0.1-100 nM 7 d) potently inhibits H3K27me3 by low-dose treatment in the sensitive lymphoma types[3]. Valemetostat (0.01 mg/g i.p. once) prevents the changes of H3K27me3 after exercise training[2]. EZH1 \| \| \| \| \| \| \| \| \| \| [1]. Daiichi Sankyo’s EZH1/2 Dual Inhibitor Valemetostat (DS-3201) Receives SAKIGAKE Designation for Treatment of Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma from Japan MHLW. [2]. Shimizu J, Kawano F. Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice. J Physiol. 2022 Jul 600(14):3331-3353. [Content Brief] [3]. Yamagishi M, et al. Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas. Cell Rep. 2019 Nov 19 29(8):2321-2337.e7. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Valemetostat.html
Last Update	2025-05-21 16:50:25

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