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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
QQ
Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameNav1.7-IN-3
SynonymsNav1.7-IN-3;Benzenesulfonamide, 5-chloro-2-fluoro-4-[[(tetrahydro-1H-pyrrolizin-7a(5H)-yl)methyl]amino]-N-2-thiazolyl-;Nav-1.7-IN-3,Nav1.7 IN 3,Nav1.7IN3
CAS1788872-06-9
EINECS
Chemical FormulaC17H20ClFN4O2S2
Molecular Weight430.95
inchi
Package1 mg;5 mg
PriceGet quote
DescriptionsNav1.7-IN-3

Nav1.7-IN-3

MedChemExpress (MCE)

HY-101789

1788872-06-9

98.21%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US

Descriptions

Nav1.7-IN-3

Nav1.7-IN-3

MedChemExpress (MCE)

HY-101789

1788872-06-9

98.21%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US
may vary elsewhere.

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.

Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes)[1].

Nav1.7 8 nM (IC50)

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[1]. Roecker AJ, et al. Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice. Bioorg Med Chem Lett. 2017 May 15
27(10):2087-2093. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/Nav1.7-IN-3.html
Last Update2025-05-21 16:50:25
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