CHMFL-ABL-121 MedChemExpress (MCE)

Product Name	CHMFL-ABL-121
Synonyms	CHMFL-ABL-121;Propanamide, N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-
CAS	2270879-07-5
EINECS
Chemical Formula	C30H31F3N6OS
Molecular Weight	580.67
inchi
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Descriptions	CHMFL-ABL-121 CHMFL-ABL-121 MedChemExpress (MCE) HY-119370 2270879-07-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions CHMFL-ABL-121 CHMFL-ABL-121 MedChemExpress (MCE) HY-119370 2270879-07-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively. CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC505050STAT5, CrkL and ErK[1]. CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1]. ABL wt 2 nM (IC50) ABL-T315I 0.2 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Liu X, et al. Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia. Eur J Med Chem. 2018 Dec 5 160:61-81. [Content Brief]
Supplier Website	https://www.medchemexpress.com/chmfl-abl-121.html
Last Update	2025-05-21 16:50:25

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