RS37619 MedChemExpress (MCE)

Product Name	Ketorolac
Synonyms	rs37619 Ketorolac Ketorolac Solution, 100ppm 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate [1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]ammonium 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid Synonyms rs37619 Ketorolac Ketorolac Solution, 100ppm 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate [1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]ammonium 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid 3-dihydro-5-benzoyl-(+-)-1h-pyrrolizine-1-carboxylicaci 1H-pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro- acide 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylique (1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
CAS	74103-06-3
EINECS	200-001-2
Chemical Formula	C15H13NO3
Molecular Weight	255.27
inchi	InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
Package	10 mM * 1 mL;50 mg;100 mg
Price	Get quote
Descriptions	Ketorolac Ketorolac MedChemExpress (MCE) HY-B0580 74103-06-3 RS37619 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Ketorolac Ketorolac MedChemExpress (MCE) HY-B0580 74103-06-3 RS37619 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research. Ketorolac (RS37619) salt (0-30 μM 48 h) effectively kills the oral cancer cells[4]. Ketorolac salt (0-5 μM 48 h) inhibits the expression of DDX3 protein, and induces apoptosis in H357 cells[4]. Ketorolac salt (0-2.5 μM 0-16 h) inhibits the proliferation of oral cancer cells[4]. Ketorolac salt (0-50 μM) directly interacts with DDX3 and inhibits the ATPase activity[4]. Ketorolac (RS37619) (0.4% ketorolac tromethamine ophthalmic solution) shows powerful ocular anti-inflammatory activities in rabbits[1]. Ketorolac (4 mg/kg/day, p.o. 2 weeks) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats[2]. Ketorolac (60 μg intrathecal injection once) attenuates the damage caused by spinal cord ischemia in rats[3]. Ketorolac salt (20 and 30 mg/kg i.p. two times in a week for 3 weeks) reduces oral carcinogenesis in mice[4]. COX-1 20 nM (IC50) COX-2 120 nM (IC50) DDX3 \| \| \| \| \| \| \| \| \| \| [1]. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun 22(6):1133-40. [Content Brief] [2]. Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec 18(6):630-4. [Content Brief] [3]. Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr 100(4):1134-9. [Content Brief] [4]. Samal SK, et al. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015 Apr 28 5:9982. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ketorolac.html
Last Update	2025-05-21 16:50:25

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