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Supplier NameMedChemExpress (MCE)
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product Name8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride
Synonyms8-Bromo-2-(1-methyl-piperidin-4-ylamino)-4-(4-phenoxy-phenylamino)-6H-pyrido[4,3-d]pyrimidin-5-one hydrochloride
CAS1457983-33-3
EINECS
Chemical FormulaC25H26BrClN6O2
Molecular Weight557.86994
inchi
PackageInquiry
PriceGet quote
DescriptionsDenfivontinib hydrochloride

Denfivontinib hydrochloride

MedChemExpress (MCE)

HY-W400801

1457983-33-3

G-749 hydrochloride

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

Denfivontinib hydrochloride

Denfivontinib hydrochloride

MedChemExpress (MCE)

HY-W400801

1457983-33-3

G-749 hydrochloride

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

Denfivontinib (G-749) hydrochloride is an AXL inhibitor that has synergistic antitumor effects with the PD-1 inhibitor Pembrolizumab (HY-P9902). Denfivontinib can enhance the NOD-like receptor pathway, thereby promoting the formation of the NLRP3 inflammasome.

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[1]. Kim DK, et al. Denfivontinib activates effector T-cells through NLRP3-inflammasome, yielding potent anticancer effects by combination with pembrolizumab. Mol Cancer Ther. 2024 Dec 5. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/denfivontinib-hydrochloride.html
Last Update2025-05-21 16:50:25
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