AZD-8931 fumarate MedChemExpress (MCE)

Product Name	diFuMaric acid
Synonyms	diFuMaric acid;AZD8931 diFumaric acid;AZD8931 difumaric acid salt;2-(4-(4-(3-CHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)-N-METHYLACETAMIDE DIFUMARIC ACID
CAS	1196531-39-1
EINECS
Chemical Formula	C31H33ClFN5O11
Molecular Weight	706.0720232
inchi
Package	Inquiry
Price	Get quote
Descriptions	Sapitinib fumarate Sapitinib fumarate MedChemExpress (MCE) HY-13050A 1196531-39-1 AZD-8931 fumarate Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Sapitinib fumarate Sapitinib fumarate MedChemExpress (MCE) HY-13050A 1196531-39-1 AZD-8931 fumarate Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Sapitinib fumarate is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively. \| \| \| \| \| \| \| \| \| \| [1]. Hickinson DM, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15 16(4):1159-69. [Content Brief] [2]. Mu Z, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models. J Exp Clin Cancer Res. 2014 May 30 33:47. [Content Brief] [3]. Barlaam B, et al. Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors. ACS Med Chem Lett. 2013 May 31 4(8):742-6. [Content Brief] [4]. Wang R, et al. Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion. Mol Cancer Res. 2018 Aug 21. pii: molcanres.0341.2018. [Content Brief]
Supplier Website	https://www.medchemexpress.com/sapitinib-fumarate.html
Last Update	2025-05-21 16:50:25

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