RO-4876904 MedChemExpress (MCE)

Product Name	(S)-1-((2S,3S,11bS)-2-amino-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl)-4-(fluoromethyl)pyrrolidin-2-one
Synonyms	R1579 RG1579 R-1579 RG-1579 Camegliptin CARMEGLIPTIN 2-Pyrrolidinone, 1-[(2S,3S,11bS)-2-amino-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-3-yl]-4-(fluoromethyl)-, (4S)- Synonyms R1579 RG1579 R-1579 RG-1579 Camegliptin CARMEGLIPTIN 2-Pyrrolidinone, 1-[(2S,3S,11bS)-2-amino-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-3-yl]-4-(fluoromethyl)-, (4S)- (S)-1-((2S,3S,11bS)-2-amino-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-3-yl)-4-(fluoromethyl)pyrrolidin-2-one
CAS	813452-18-5
EINECS
Chemical Formula	C20H28FN3O3
Molecular Weight	377
inchi
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Descriptions	Carmegliptin Carmegliptin MedChemExpress (MCE) HY-10289 813452-18-5 RO-4876904 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Carmegliptin Carmegliptin MedChemExpress (MCE) HY-10289 813452-18-5 RO-4876904 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Carmegliptin (RO-4876904) is an orally active, potent and long-acting dipeptidyl peptidase IV inhibitor. Carmegliptin is also a substrate of P-glycoprotein that synergizes with Verapamil (HY-14275). Carmegliptin improves insulin sensitivity and reduces hepatic glucose production in hyperglycemic mice. Carmegliptin is promising for research of type 2 diabetes, hypertension and cardiovascular disease. DPP-4 \| \| \| \| \| \| \| \| \| \| [1]. Mattei P, et al. Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2010 Feb 1 20(3):1109-13. [Content Brief] [2]. Kuhlmann O, et al. Interaction potential of Carmegliptin with P-glycoprotein (Pgp) transporter in healthy volunteers. J Drug Assess. 2014 Mar 3 3(1):28-37. [Content Brief]
Supplier Website	https://www.medchemexpress.com/carmegliptin.html
Last Update	2025-04-01 14:45:47

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