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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameGenz 669178(Genz669178)
SynonymsGenz 669178(Genz669178);Genz 669178;2-Thiophenecarboxamide, 5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropyl-;Genz 669178 (Genz669178)
CAS1254834-91-7
EINECS
Chemical FormulaC17H14N4OS
Molecular Weight322.38
inchi
PackageInquiry
PriceGet quote
DescriptionsGenz-669178

Genz-669178

MedChemExpress (MCE)

HY-120462

1254834-91-7

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

Genz-669178

Genz-669178

MedChemExpress (MCE)

HY-120462

1254834-91-7

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice.

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[1]. Booker ML, et al., Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22
285(43):33054-33064. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/genz-669178.html
Last Update2025-05-21 16:50:25
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