PFM046 MedChemExpress (MCE)

Product Name	Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester
Synonyms	Carbamic acid, N-[3-chloro-5-[1-[[6-[2-(5-ethyl-4-methyl-2-thiazolyl)ethyl]-4-(4-morpholinyl)-2-pyridinyl]amino]ethyl]phenyl]-, 1-methylethyl ester;J 115814J-115814;J115814;J-115814;UNII-81DP93CF8M
CAS	329716-61-2
EINECS
Chemical Formula	C29H38ClN5O3S
Molecular Weight	572.16
inchi
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Descriptions	J-115814 J-115814 MedChemExpress (MCE) HY-122021 329716-61-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions J-115814 J-115814 MedChemExpress (MCE) HY-122021 329716-61-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors. J-115814 (0.3, 1, 3, 10 mg/kg i.v.) inhibits NPY-induced feeding in SD rats[1]. J-115814 (3, 10, 30 mg/kg i.p.) shows anorexigenic effect in mice[1]. hY1 receptor 1.4 nM (Ki) rNPY Y1 receptor 1.8 nM (Ki) mY1 1.9 nM (Ki) hY4 receptor 620 nM (Ki) hY5 receptor 6000 nM (Ki) human Y2 receptor >10000 nM (Ki) mY6 >10000 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Kanatani A, et al. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol. 2001 Mar 59(3):501-5. [Content Brief]
Supplier Website	https://www.medchemexpress.com/j-115814.html
Last Update	2025-05-21 16:50:25

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