ER ligand-6 MedChemExpress (MCE)

Product Name	GPI 15427
Synonyms	GPI 15427;DZRLVSOGARUEGQ-UHFFFAOYSA-N;[1]Benzopyrano[4,3,2-de]phthalazin-3(2H)-one, 10-[(4-methyl-1-piperazinyl)methyl]-
CAS	805242-85-7
EINECS
Chemical Formula	C20H20N4O2
Molecular Weight	348.4
inchi
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Descriptions	GPI 15427 GPI 15427 MedChemExpress (MCE) HY-15048 805242-85-7 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions GPI 15427 GPI 15427 MedChemExpress (MCE) HY-15048 805242-85-7 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation. \| \| \| \| \| \| \| \| \| \| [1]. Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock
Supplier Website	https://www.medchemexpress.com/gpi-15427.html
Last Update	2025-05-21 16:50:25

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