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Supplier NameMedChemExpress (MCE)
Contactsales
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Emailsales@medchemexpress.com; tech@medchemexpress.com
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Product NameBRL 44408 MALEATE
SynonymsBRL 44408 MALEATE
CAS118343-19-4
EINECS
Chemical FormulaC17H21N3O4
Molecular Weight331.37
inchi
PackageInquiry
PriceGet quote
DescriptionsBRL-44408

BRL-44408

MedChemExpress (MCE)

HY-12716

118343-19-4

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

BRL-44408

BRL-44408

MedChemExpress (MCE)

HY-12716

118343-19-4

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

BRL-44408 is a selective adrenergic receptor antagonist of α2A/α2B AR. BRL-44408 can effectively antagonize the inhibitory effects of norepinephrine or adrenergic receptor agonist Clonidine (HY-12721) on K+-induced [3H]norepinephrine and [3H]5-hydroxytryptamine release. BRL-44408 has a higher affinity for human platelet membranes containing α2A-adrenoceptors than BRL-41992 and Imiloxan (HY-101337). BRL-44408 may affect the release of norepinephrine and 5-hydroxytryptamine through a mechanism mediated by α2A-adrenoceptors, and has a potential role in the regulation of neurotransmitter release.

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[1]. Further Studies on a2-Adrenofeptor Subtypes Involved in the Modulation of [ HINoradrenaline and [3H]5-Hydroxytryptamine Release from Rat Brain Cortex Synaptosomes

Supplier Websitehttps://www.medchemexpress.com/brl-44408.html
Last Update2025-05-21 16:50:25
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