CP 868596-26 MedChemExpress (MCE)

Product Name	Crenolanib
Synonyms	[1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine mono(benzenesulfonate) 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine. PhSO3H Synonyms [1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine mono(benzenesulfonate) 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine. PhSO3H 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzimidazol-1-yl)quinolin-8-yl)piperidin-4- amine monobenzenesulfonate 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine benzenesulfonate CP-868596
CAS	670220-93-6
EINECS
Chemical Formula	C32H35N5O5S
Molecular Weight	601.72
inchi
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Descriptions	Crenolanib benzenesulfonate Crenolanib benzenesulfonate MedChemExpress (MCE) HY-13223A 670220-93-6 CP 868596-26 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Crenolanib benzenesulfonate Crenolanib benzenesulfonate MedChemExpress (MCE) HY-13223A 670220-93-6 CP 868596-26 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Crenolanib benzenesulfonate is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively. Kd: 2.1 nM (PDGFRα), 3.2 nM (PDGFRβ), 0.74 nM (FLT3) Molecular Weight 601.72 \| \| \| \| \| \| \| \| \| \| [1]. Mathias TJ, et al. The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations. Invest New Drugs. 2015 Apr 33(2):300-9. [Content Brief] [2]. Wang P, et al. Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo. Onco Targets Ther. 2014 Sep 26 7:1761-8. [Content Brief] [3]. Heinrich MC, et al.Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with STI571-resistant gastrointestinal stromal tumors. Clin Cancer Res, 2012, Jun 27. [Content Brief]
Supplier Website	https://www.medchemexpress.com/crenolanib-benzenesulfonate.html
Last Update	2025-05-21 16:50:25

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