BIRB 796 (GMP) MedChemExpress (MCE)

Product Name	Doramapimod
Synonyms	CS-379 CS-1863 BIRB 796 BIRB796 BIBR-796 BIRB-796 Doramapimod Synonyms CS-379 CS-1863 BIRB 796 BIRB796 BIBR-796 BIRB-796 Doramapimod 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
CAS	285983-48-4
EINECS	1308068-626-2
Chemical Formula	C31H37N5O3
Molecular Weight	527.66
inchi	InChI=1/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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Descriptions	Doramapimod (GMP) Doramapimod (GMP) MedChemExpress (MCE) HY-10320G 285983-48-4 BIRB 796 (GMP) Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Doramapimod (GMP) Doramapimod (GMP) MedChemExpress (MCE) HY-10320G 285983-48-4 BIRB 796 (GMP) Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC50s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity. p38α 38 nM (IC50) p38β 65 nM (IC50) p38γ 200 nM (IC50) p38δ 520 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Cicenas J, et al., JNK, p38, ERK, and SGK1 Inhibitors in Cancer. Cancers (Basel). 2017 Dec 21 10(1):1. [Content Brief]
Supplier Website	https://www.medchemexpress.com/doramapimod-gmp.html
Last Update	2025-05-21 16:50:25

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