Metoclopramide MedChemExpress (MCE)

Product Name	CHF-4227
Synonyms	CHF-4227
CAS	444643-64-5
EINECS
Chemical Formula	C30H33NO4
Molecular Weight	471.59
inchi
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Descriptions	CHF 4227 free base CHF 4227 free base MedChemExpress (MCE) HY-107045 444643-64-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions CHF 4227 free base CHF 4227 free base MedChemExpress (MCE) HY-107045 444643-64-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. CHF 4227 free base is an orally active and selective estrogen receptor modulator (SERM) with high affinity to the human estrogen receptor-α and -β (Ki values of 0.017 nM and 0.099 nM, respectively). In immature rats, oral administration of CHF 4227 free base for 3 days inhibited the uterotrophic action of Ethinylestradiol (EE2) (HY-B0216) (ED50DMBA (HY-W011845)-induced mammary tumors, the incidence being reduced from 87.5 to 26.3% 6 months after DMBA administration[1]. In ovariectomized (OVX) rats treated orally for 4 weeks, CHF 4227 free basecompletely inhibits OVX effects on bone density (ED50[1]. CHF 4227 free base reduces serum cholesterol (ED50[1]. hERα 0.017 nM (Ki) hERβ 0.099 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Elisabetta Galbiati, et al. Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen. J Pharmacol Exp Ther. 2002 Oct 303(1):196-203. [Content Brief] [2]. Maurizio Civelli, et al. Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women. Br J Clin Pharmacol. 2007 Sep 64(3):304-16. [Content Brief]
Supplier Website	https://www.medchemexpress.com/chf-4227-free-base.html
Last Update	2025-05-21 16:50:25

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