TTA-A8 MedChemExpress (MCE)

Product Name	TTA-A8
Synonyms	TTA-A8 2-[4-(3-methylpyrazin-2-yl)phenyl]-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide Benzeneacetamide, 4-(3-methyl-2-pyrazinyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-
CAS	1146395-46-1
EINECS
Chemical Formula	C22H21F3N4O2
Molecular Weight	430.42
inchi
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Descriptions	TTA-A8 TTA-A8 MedChemExpress (MCE) HY-14232 1146395-46-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions TTA-A8 TTA-A8 MedChemExpress (MCE) HY-14232 1146395-46-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. TTA-A8 (Compound 13) is a short-acting T-type calcium channel antagonist with oral activity, exhibiting an IC50 value of 31.3 nM in the FLIPR depolarization assay. TTA-A8 possesses favorable pharmacokinetic properties, making it suitable for research on epilepsy and sleep. TTA-A8 (3 mg/kg p.o. single dose) effectively shortened the duration of epileptic seizures in Wistar albino rats with genetic absence epilepsy. TTA-A8 (1-10 mg/kg p.o. single dose) significantly suppressed active wake and increased delta wave sleep in SD rats[1]. TTA-A8 (5 mg/kg p.o. single dose) exhibited moderate to high plasma clearance (CLp), low to moderate distribution volume (Vss), and short half-life (T1/2) across three preclinical species (rat, dog, rhesus)[1]. Pharmacokinetic parameters in rat, dog, rhesus[1] species administration dosage CL (predicted)a(mL/min/kg) CLp(observed)(mL/min/kg) T1/2(h) Vss (L/kg) F (%) plasma PB (% unbound)b rat p.o. 5 mg/kg 8 30.3 0.24 0.59 71 12.3 dog p.o. 5 mg/kg 13 11.8 0.81 0.36 23 15.5 rhesus p.o. 5 mg/kg 22 19.3 0.53 0.74 5 14.6 \| \| \| \| \| \| \| \| \| \| [1]. Yang Z Q, et al. Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents[J]. ACS Medicinal Chemistry Letters, 2010, 1(9): 504-509. [Content Brief]
Supplier Website	https://www.medchemexpress.com/tta-a8.html
Last Update	2025-05-21 16:50:25

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