TC-1698 MedChemExpress (MCE)

Product Name	2-(3-PYRIDINYL)-1-AZABICYCLO[3.2.2]NONANE DIHYDROCHLORIDE
Synonyms	2-(3-PYRIDINYL)-1-AZABICYCLO[3.2.2]NONANE DIHYDROCHLORIDE
CAS	700834-58-8
EINECS
Chemical Formula	C13H20Cl2N2
Molecular Weight
inchi
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Descriptions	TC-1698 TC-1698 MedChemExpress (MCE) HY-107668A 700834-58-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions TC-1698 TC-1698 MedChemExpress (MCE) HY-107668A 700834-58-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer's disease research. \| \| \| \| \| \| \| \| \| \| [1]. Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8 54(23):7943-61. [Content Brief] [2]. Marrero MB, et al. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr 309(1):16-27. [Content Brief] [3]. Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7 524(1-3):11-8. [Content Brief]
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Last Update	2025-05-21 16:50:25

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