Pyrazinamide-d3 MedChemExpress (MCE)

Product Name	PyrazinaMide-d3
Synonyms	PyrazinaMide-d3;Pyrazinamide-3,5,6-[d3]
CAS	1432059-16-9
EINECS
Chemical Formula	C5H2D3N3O
Molecular Weight	126.131185334
inchi
Package	1 mg
Price	Email to quote
Descriptions	Pyrazinamide-d3 Pyrazinamide-d3 MedChemExpress (MCE) HY-B0271S 1432059-16-9 Pyrazinecarboxamide-d3 Descriptions Pyrazinamide-d3 Pyrazinamide-d3 MedChemExpress (MCE) HY-B0271S 1432059-16-9 Pyrazinecarboxamide-d3 Pyrazinoic acid amide-d3 99.84% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr 181(7):2044-9. [Content Brief] [3]. Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug 2(4):MGM2-0023-2013. [Content Brief]
Supplier Website	https://www.medchemexpress.com/pyrazinamide-d3.html
Last Update	2025-05-21 16:50:25

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