Atibuclimab MedChemExpress (MCE)

Product Name	Atibuclimab
Synonyms	Atibuclimab
CAS	2417175-94-9
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Atibuclimab Atibuclimab MedChemExpress (MCE) HY-P99008 2417175-94-9 97.74% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis. Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Chimeric Human IgG4 kappa Human IgG4 (S228P) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Henderson RD, Agosti JM, McCombe PA, et al. Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis. Medicine (Baltimore). 2021 Descriptions Atibuclimab Atibuclimab MedChemExpress (MCE) HY-P99008 2417175-94-9 97.74% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis. Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Chimeric Human IgG4 kappa Human IgG4 (S228P) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Henderson RD, Agosti JM, McCombe PA, et al. Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis. Medicine (Baltimore). 2021 100(42):e27421. [Content Brief] [2]. Verbon A, et al. IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J Immunol. 2001 166(5):3599-3605. [Content Brief]
Supplier Website	https://www.medchemexpress.com/atibuclimab.html
Last Update	2025-05-21 16:50:25

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