CKK-E12 MedChemExpress (MCE)

Product Name	2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-
Synonyms	CKK-E12(MD-1);2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-
CAS	1432494-65-9
EINECS
Chemical Formula	C60H120N4O6
Molecular Weight	993.62
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	CKK-E12 CKK-E12 MedChemExpress (MCE) HY-134781 1432494-65-9 98.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions CKK-E12 CKK-E12 MedChemExpress (MCE) HY-134781 1432494-65-9 98.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo, CKK-E12 delivers siRNA in mice, rats and primates (ED50 is 0.002, 0.01 and 0.3 mg/kg, respectively)[1]. \| \| \| \| \| \| \| \| \| \| [1]. Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15 111(15):5753]. Proc Natl Acad Sci U S A. 2014 111(11):3955-3960. [Content Brief] [2]. Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017 17(3):1326-1335. [Content Brief] [3]. Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar 17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ckk-e12.html
Last Update	2025-05-21 16:50:25

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