Yohimbine-13C,d3 MedChemExpress (MCE)

Product Name	Yohimbine-[13C,D3]
Synonyms	Yohimbine-[13C,D3]
CAS	1261254-59-4
EINECS
Chemical Formula	C21H23D3N2O3
Molecular Weight	358.470225334
inchi
Package	1 mg
Price	Email to quote
Descriptions	Yohimbine-13C,d3 Yohimbine-13C,d3 MedChemExpress (MCE) HY-12715S 1261254-59-4 99.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Yohimbine-13C,d3 Yohimbine-13C,d3 MedChemExpress (MCE) HY-12715S 1261254-59-4 99.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Yohimbine-13C,d3 is the 13C- and deuterium labeled Yohimbine. Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Saeed SA, et al. Signaling mechanisms mediated by G-protein coupled receptors in human platelets. Acta Pharmacol Sin. 2004 Jul 25(7):887-892. [Content Brief] [3]. Blanchard RJ, et al. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice. Pharmacol Biochem Behav. 1993 Mar 44(3):673-681. [Content Brief] [4]. Fuller BB, et al. Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol. 2000 Feb 114(2):268-276. [Content Brief]
Supplier Website	https://www.medchemexpress.com/yohimbine-13c-d3.html
Last Update	2025-05-21 16:50:25

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