Isolithocholic acid MedChemExpress (MCE)

Product Name	(3β,5β)-3-Hydroxycholan-24-oic acid
Synonyms	isoLCA Isolithocholic acid (ILCA) (3β,5β)-3-Hydroxycholan-24-oic acid (3β,5β)-3-Hydroxycholan-24-oic acid (3beta,5beta)-3-Hydroxycholan-24-oic Acid (R)-4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid Synonyms isoLCA Isolithocholic acid (ILCA) (3β,5β)-3-Hydroxycholan-24-oic acid (3β,5β)-3-Hydroxycholan-24-oic acid (3beta,5beta)-3-Hydroxycholan-24-oic Acid (R)-4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid (4R)-4-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS	1534-35-6
EINECS
Chemical Formula	C24H40O3
Molecular Weight	376.57
inchi
Package	10 mM * 1 mL;1 mg;5 mg
Price	Email to quote
Descriptions	Isolithocholic acid Isolithocholic acid MedChemExpress (MCE) HY-B0172B 1534-35-6 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Isolithocholic acid Isolithocholic acid MedChemExpress (MCE) HY-B0172B 1534-35-6 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. Isolithocholic acid at 0.01 % does not inhibit spore germination and outgrowth of CF5 and M120, but it significantly inhibits at the higher concentration (0.1 %). Isolithocholic acid (0.00003 %) prevents growth of CD196, M68, CF5, 630, and BI9 and significant decreases strains CF5, BI9, M120, and 630 in toxin activity. Isolithocholic acid (0.0003 %) makes that all strains displays a significant decrease in toxin activity, except for R20291 and M120[3]. The levels of fecal Isolithocholic acid shows obvious decreases from day 28 onward in the high fat diet (HFD) group compared with rats fed a normal diet[4]. Microbial Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Batta AK, et al. Transformation of bile acids into iso-bile acids by Clostridium perfringens: possible transport of 3 beta-hydrogen via the coenzyme. Hepatology. 1985 5(6):1126-1131. [Content Brief] [2]. Borriello SP, et al. The metabolism of lithocholic acid and lithocholic acid-3-alpha-sulfate by human fecal bacteria. Lipids. 1982 17(7):477-482. [Content Brief] [3]. Thanissery R, et al. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. Anaerobe. 2017 45:86-100. [Content Brief] [4]. Lin H, et al. Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model. J Agric Food Chem. 2019 67(13):3624-3632. [Content Brief]
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Last Update	2025-04-01 14:45:47

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