Asimilobine MedChemExpress (MCE)

Product Name	asimilobine
Synonyms	asimilobine;R-(-)-asimilobine;1-Methoxy-6abeta-noraporphin-2-ol;(R)-5,6,6a,7-Tetrahydro-1-methoxy-4H-dibenzo[de,g]quinolin-2-ol;4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-, (6aR)-
CAS	6871-21-2
EINECS
Chemical Formula	C17H17NO2
Molecular Weight	267.32
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Asimilobine Asimilobine MedChemExpress (MCE) HY-N7512 6871-21-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Asimilobine Asimilobine MedChemExpress (MCE) HY-N7512 6871-21-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity. Asimilobine (0.05-0.2 μM for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM[2]. Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h[2]. Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels[2]. Plasmodium Dopamine Receptor serotonergic receptor \| \| \| \| \| \| \| \| \| \| [1]. N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987 50(4):773-4. [Content Brief] [2]. Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008 10(7-8):747-55. [Content Brief]
Supplier Website	https://www.medchemexpress.com/asimilobine.html
Last Update	2025-05-21 16:50:25

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