Hexa-D-arginine TFA MedChemExpress (MCE)

Product Name	Furin Inhibitor II TFA
Synonyms	Hexa-D-arginine TFA;Furin Inhibitor II TFA
CAS	958204-56-3
EINECS
Chemical Formula	C38H76F3N25O8
Molecular Weight	1068.19
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Hexa-D-arginine TFA Hexa-D-arginine TFA MedChemExpress (MCE) HY-P1028A 958204-56-3 Furin Inhibitor II TFA 98.42% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions Hexa-D-arginine TFA Hexa-D-arginine TFA MedChemExpress (MCE) HY-P1028A 958204-56-3 Furin Inhibitor II TFA 98.42% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo. Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1]. Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1]. Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)[3] In Vitro Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Hexa-D-arginine TFA Related Antibodies d(Arg-Arg-Arg-Arg-Arg-Arg)-NH2 \| \| \| \| \| \| \| \| \| \| [1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec 70(12):7136-9. [Content Brief] [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan 72(1):602-5. [Content Brief] [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24 275(47):36741-9. [Content Brief]
Supplier Website	https://www.medchemexpress.com/hexa-d-arginine-tfa.html
Last Update	2025-05-21 16:50:25

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