2-Furoyl-LIGRLO-amide MedChemExpress (MCE)

Product Name	2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
Synonyms	2F-LIGRLO-AMIDE PAR-2 AGONIST II 2-FUROYL-LIGRLO-AMIDE 2-(2-FUROYL)-LIGRLOAMIDE 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II Synonyms 2F-LIGRLO-AMIDE PAR-2 AGONIST II 2-FUROYL-LIGRLO-AMIDE 2-(2-FUROYL)-LIGRLOAMIDE 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II 2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT)
CAS	729589-58-6
EINECS
Chemical Formula	C36H63N11O8
Molecular Weight	777.95
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	2-Furoyl-LIGRLO-amide 2-Furoyl-LIGRLO-amide MedChemExpress (MCE) HY-P1314 729589-58-6 99.87% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions 2-Furoyl-LIGRLO-amide 2-Furoyl-LIGRLO-amide MedChemExpress (MCE) HY-P1314 729589-58-6 99.87% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. 2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0.. 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1]. In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1]. Furoyl-LIGRLO-amide (injected intradermally at the nape of the neck 10 μg pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3-/- mice. But it decreases significantly the number of scratches in WT mice[1]. PAR2 \| \| \| \| \| \| \| \| \| \| [1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun 309(3):1124-31. [Content Brief] [2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul 26(7):2877-87. [Content Brief] [3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol [Content Brief]
Supplier Website	https://www.medchemexpress.com/2-furoyl-ligrlo-amide.html
Last Update	2025-05-21 16:50:25

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