Amiloride-15N3 hydrochloride MedChemExpress (MCE)

Product Name	Amiloride-15N3 Hydrochloride
Synonyms	Nilurid-15N MidaMor-15N3 Colectril-15N3 AMipraMidine-15N3 AMipraMizide-15N3 AMILORIDE-15N3 HYDROCHLORIDE Amiloride-15N3 Hydrochloride Synonyms Nilurid-15N MidaMor-15N3 Colectril-15N3 AMipraMidine-15N3 AMipraMizide-15N3 AMILORIDE-15N3 HYDROCHLORIDE Amiloride-15N3 Hydrochloride N-AMidino-3,5-diaMino-6-chloropyrazinaMide-15N3 Hydrochloride 3,5-DiaMino-N-(aMinoiMinoMethyl)-6-chloro-2-pyrazinecarboxaMide-15N3 Hydrochloride
CAS	1216796-18-7
EINECS
Chemical Formula	C6H9Cl2N7O
Molecular Weight	266.08796
inchi
Package	1 mg
Price	Email to quote
Descriptions	Amiloride-15N3 hydrochloride Amiloride-15N3 hydrochloride MedChemExpress (MCE) HY-B0285AS 1216796-18-7 MK-870-15N3 hydrochloride Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Amiloride-15N3 hydrochloride Amiloride-15N3 hydrochloride MedChemExpress (MCE) HY-B0285AS 1216796-18-7 MK-870-15N3 hydrochloride Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2 TRPP2[4]) channel. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb 53(2):211-216. [Content Brief] [2]. Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26. [Content Brief] [3]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan20(1):109-17. [Content Brief] [4]. Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 729(7):1176-91. [Content Brief]
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Last Update	2025-05-21 16:50:25

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