Valsartan-d3 MedChemExpress (MCE)

Product Name	Valsartan-d3
Synonyms	Nisis-d3 Tareg-d3 Diovan-d3 VALSARTAN-D3 CGP 48933-d3 Valsartan-d3 N-(1-Oxopentyl-d3)-N-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-L-valine, Synonyms Nisis-d3 Tareg-d3 Diovan-d3 VALSARTAN-D3 CGP 48933-d3 Valsartan-d3 N-(1-Oxopentyl-d3)-N-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-L-valine, N-(1-Oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-L-valine-d3 (2S)-3-methyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl-(5,5,5-trideuteriopentanoyl)amino]butanoic acid
CAS	1331908-02-1
EINECS
Chemical Formula	C24H26D3N5O3
Molecular Weight	438.537245334
inchi
Package	1 mg
Price	Email to quote
Descriptions	Valsartan-d3 Valsartan-d3 MedChemExpress (MCE) HY-18204S1 1331908-02-1 CGP 48933-d3 94.36% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Valsartan-d3 Valsartan-d3 MedChemExpress (MCE) HY-18204S1 1331908-02-1 CGP 48933-d3 94.36% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Valsartan-d3 is the deuterium labeled Valsartan[1]. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[2]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb 53(2):211-216. [Content Brief] [2]. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun 18(6):1071-80. [Content Brief] [3]. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct 38(10):2529-40. [Content Brief] [4]. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug 19(8):1773-82. [Content Brief] [5]. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug 24(4):224-9. [Content Brief] [6]. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep 124:5-12. [Content Brief]
Supplier Website	https://www.medchemexpress.com/valsartan-d3.html
Last Update	2025-05-21 16:50:25

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