Dosimertinib mesylate MedChemExpress (MCE)

Product Name	2-Propenamide-3,3-d2, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(methyl-d3)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)
Synonyms	2-Propenamide-3,3-d2, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(methyl-d3)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)
CAS	2403760-72-3
EINECS
Chemical Formula	C28H28D5N7O2.CH4O3S
Molecular Weight	600.75
inchi
Package	1 mg
Price	Email to quote
Descriptions	Dosimertinib-d5 mesylate Dosimertinib-d5 mesylate MedChemExpress (MCE) HY-142283AS 2403760-72-3 99.44% -20°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Dosimertinib-d5 mesylate Dosimertinib-d5 mesylate MedChemExpress (MCE) HY-142283AS 2403760-72-3 99.44% -20°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Dosimertinib-d5 (mesylate) is a potent and orally active EGFR inhibitor. Dosimertinib-d5 (mesylate) decreases the expression of p-EGFR and p-ERK protein levels. Dosimertinib-d5 (mesylate) shows antiproliferative and anti-tumor activity. Dosimertinib-d5 (mesylate) has the potential for the research of non-small-cell lung cancer (NSCLC)[1]. Dosimertinib mesylate (compound 2h) (1, 10, 100, 100 nM 2h) decreases the expression of p-EGFR and p-ERK protein levels in a dose-dependent manner[1]. Dosimertinib mesylate (0.75, 1.5, 3 mg/kg oral gavage, daily for 24 days) shows anti-tumor activity in mouse[1]. Pharmacokinetic Parameters of Dosimertinib mesylate in Sprague-Dawley rats[1]. detected compound dosimertinib administration route i.v. i.g. i.g. i.g. dose (mg/kg) 2 2 6 12 C0 or Cmax (nM) 277 ± 105 46.7 ± 10.7 113 ± 19.8 283 ± 137 Tmax (h) 4.17 ± 2.56 4.67 ± 1.63 5.00 ± 1.67 t1/2 (h) 5.40 ± 1.84 3.76 ± 1.08 3.27 ± 0.43 4.04 ± 1.50 AUC0-t (nM·h) 1070 ± 565 459 ± 191 1020 ± 313 2830 ± 1780 CL/F (L/h/kg) 22.3 ± 11.1 32.2 ± 13.6 19.5 ± 5.1 14.9 ± 6.4 bioavailability (%) 41.2 29.6 43.0 Sprague-Dawley rats, 2 mg/kg iv 2, 6, 12 mg/kg for i.g.. \| \| \| \| \| \| \| \| \| \| [1]. Meng Y, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28 64(2):925-937. [Content Brief]
Supplier Website	https://www.medchemexpress.com/dosimertinib-mesylate.html
Last Update	2025-05-21 16:50:25

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