Frexalimab MedChemExpress (MCE)

Product Name	Frexalimab
Synonyms	Frexalimab
CAS	2515463-86-0
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	Frexalimab Frexalimab MedChemExpress (MCE) HY-P99625 2515463-86-0 SAR441344 Descriptions Frexalimab Frexalimab MedChemExpress (MCE) HY-P99625 2515463-86-0 SAR441344 INX-021 99.00% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the CD40 ligand (CD40L) with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sjögren’s syndrome and type I diabetes research. Frexalimab is a second-generation anti-CD40L humanized IgG1 monoclonal antibody that has been Fc-engineered. The Fc engineering abrogates the platelet activation that is triggered by FcγRIIa stimulation by immune complexes[2]. Chimeric Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Bruce A C Cree, et al. New drugs for multiple sclerosis: new treatment algorithms. Curr Opin Neurol. 2022 Jun 1 35(3):262-270. [Content Brief] [2]. Vermersch P, et al. Inhibition of CD40L with Frexalimab in Multiple Sclerosis. N Engl J Med. 2024 Feb 15 390(7):589-600. [Content Brief] [3]. Carvalho T. Anti-CD40L antibody frexalimab slows new brain lesions in multiple sclerosis. Nat Med. 2023 Aug 29(8):1882-1883. [Content Brief] [4]. Weiskorn J, et al. Moving from Insulin Substitution to the Treatment of the Underlying Autoimmune Disease in Type 1 Diabetes. Horm Res Paediatr. 2024 Apr 30:1-8. [Content Brief] [5]. Maddaloni E, et al. Immune checkpoint modulators in early clinical development for the treatment of type 1 diabetes. Expert Opin Investig Drugs. 2024 Apr 33(4):303-318. [Content Brief]
Supplier Website	https://www.medchemexpress.com/frexalimab.html
Last Update	2025-05-21 16:50:25

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