Talacotuzumab MedChemExpress (MCE)

Product Name	Talacotuzumab
Synonyms	Talacotuzumab
CAS	1826831-79-1
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	Talacotuzumab Talacotuzumab MedChemExpress (MCE) HY-P99395 1826831-79-1 JNJ 56022473 Descriptions Talacotuzumab Talacotuzumab MedChemExpress (MCE) HY-P99395 1826831-79-1 JNJ 56022473 CSL 362 98.82% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Talacotuzumab (JNJ 56022473 CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models. Talacotuzumab (JNJ 56022473 CSL 362) strongly mediates ADCC of TF-1 cells with an ic50 of 5 ng/ml (33 pM)[1]. Talacotuzumab (1 μg/ml pretreatment for 24 hours) inhibits TLR7-stimulated (Imiquimod HY-B0180 0.5 μM for 6 days) and TLR9-stimulated (CpG C 0.5 μM for 6 days) IFN-α production in both SLE donors and healthy donors plasmacytoid dendritic cells (pDCs) and basophils, whereas TLR4-stimulated (LPS HY-D1056 10 μg/ml) production is not significantly reduced. Talacotuzumab inhibits TLR7- and TLR9-induced plasmablast expansion and proliferation by depletion of plasmacytoid dendritic cells (pDCs)[2]. Talacotuzumab (JNJ 56022473 CSL 362 300 μg ip thrice weekly for 5 weeks) results in a significant delay in tumor growth compared with an isotype control in acute myeloid leukaemia mice xenografts[1]. Talacotuzumab (1, 10, 30 mg/kg s.c. single injection) has maximal serum concentrations at 48 hours of ~12, 190, and 380 μg/ml at doses of 1, 10, and 30 mg/kg in naive cynomolgus monkeys, respectively[2]. Humanized Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. S J Busfield, et al. Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC. Leukemia. 2014 Nov 28(11):2213-21. [Content Brief] [2]. Shereen Oon, et al. A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus. JCI Insight. 2016 May 5 1(6):e86131. [Content Brief] [3]. Erwin M Lee, et al. Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice. Haematologica. 2015 Jul 100(7):914-26. [Content Brief] [4]. L H Xie, et al. CD123 target validation and preclinical evaluation of ADCC activity of anti-CD123 antibody CSL362 in combination with NKs from AML patients in remission. Blood Cancer J. 2017 Jun 2 7(6):e567. [Content Brief]
Supplier Website	https://www.medchemexpress.com/talacotuzumab.html
Last Update	2025-05-21 16:50:25

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