Navicixizumab MedChemExpress (MCE)

Product Name	Navicixizumab
Synonyms	Navicixizumab
CAS	1638338-43-8
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Navicixizumab Navicixizumab MedChemExpress (MCE) HY-P99377 1638338-43-8 OMP-305B83 Descriptions Navicixizumab Navicixizumab MedChemExpress (MCE) HY-P99377 1638338-43-8 OMP-305B83 Anti-DLL4 Reference Antibody (navicixizumab) Please store the product under the recommended conditions in the Certificate of Analysis. Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel.html" target="_blank"> Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer. Navicixizumab (0-100 μM) reduces proliferation of human endothelial cells in the presence of hVEGF[3]. Navicixizumab (15 mg/kg, once a week for 4 weeks) inhibits colon xenograft tumor growth[3]. IC50: hVEGF (0.36 nM), mVEGF (25.5 nM), hDLL4 (1.3 nM) In Vitro Navicixizumab (0-100 μM) reduces proliferation of human endothelial cells in the presence of hVEGF[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Navicixizumab Related Antibodies Bispecific Human IgG2 kappa Human IgG2 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Fu S, et al. Phase Ib Study of Navicixizumab Plus Paclitaxel in Patients With Platinum-Resistant Ovarian, Primary Peritoneal, or Fallopian Tube Cancer. J Clin Oncol. 2022 Aug 10 40(23):2568-2577. [Content Brief] [2]. Perez-Fidalgo JA, et al. NOTCH signalling in ovarian cancer angiogenesis. Ann Transl Med. 2020 Dec 8(24):1705. [Content Brief] [3]. Wan-Ching Yen, et al. Abstract C164: Dual targeting of the DLL4 and VEGF pathways with a bispecific monoclonal antibody inhibits tumor growth and reduces cancer stem cell frequency. Mol Cancer Ther (2015) 14 (12_Supplement_2): C164.
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Last Update	2025-05-21 16:50:25

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