Oxychlororaphine MedChemExpress (MCE)

Product Name	Phenazine-1-carboxamide
Synonyms	Oxychloraphine;Oxychloroaphine;Oxychlororaphine;1-Phenazinecarboxamide;Phenazine-1-carboxamide;phenazine-1-carboxamide;Oxychloraphin, Phenazine-1-carboxyaMide, Xanthoraphine
CAS	550-89-0
EINECS
Chemical Formula	C13H9N3O
Molecular Weight	223.23
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Oxychlororaphine Oxychlororaphine MedChemExpress (MCE) HY-W042191 550-89-0 98.90% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Oxychlororaphine Oxychlororaphine MedChemExpress (MCE) HY-W042191 550-89-0 98.90% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer. Oxychloroaphine (1-256 μM 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM[2]. Oxychloroaphine (1-150 μM A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein[2]. Oxychloroaphine (32 μM A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase[2]. Oxychloroaphine (48 h A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP[2]. \| \| \| \| \| \| \| \| \| \| [1]. Li S, et, al. Comparative metabolomics and transcriptomics analyses provide insights into the high-yield mechanism of phenazines biosynthesis in Pseudomonas chlororaphis GP72. J Appl Microbiol. 2022 Nov 133(5):2790-2801. [Content Brief] [2]. Ali HM, et, al. Isolation of Bioactive Phenazine-1-Carboxamide from the Soil Bacterium Pantoea agglomerans and Study of Its Anticancer Potency on Different Cancer Cell Lines. J AOAC Int. 2016 Sep 99(5):1233-9. [Content Brief]
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Last Update	2025-05-21 16:50:25

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