Rilmenidine-d4 MedChemExpress (MCE)

Product Name	Rilmenidine-d4
Synonyms	Rilmenidine-d4;4,4,5,5-tetradeuterio-N-(dicyclopropylmethyl)-1,3-oxazol-2-amine
CAS	85047-14-9
EINECS	604-604-1
Chemical Formula	C10H12D4N2O
Molecular Weight	184.271487112
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Package	1 mg;5 mg
Price	Email to quote
Descriptions	Rilmenidine-d4 Rilmenidine-d4 MedChemExpress (MCE) HY-100490S 85047-14-9 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Rilmenidine-d4 Rilmenidine-d4 MedChemExpress (MCE) HY-100490S 85047-14-9 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Rilmenidine-d4 is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000 13(6 Pt 2):106S-111S. [Content Brief] [3]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016 81:172-180. [Content Brief] [4]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010 19(11):2144-2153. [Content Brief]
Supplier Website	https://www.medchemexpress.com/rilmenidine-d4.html
Last Update	2025-05-21 16:50:25

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