Rosiglitazone-d3 MedChemExpress (MCE)

Product Name	Rosiglitazone-d3
Synonyms	Rosiglitazone-d3;[2H3]-Rosiglitazone;5-[[4-[2-[pyridin-2-yl(trideuteriomethyl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS	1132641-22-5
EINECS
Chemical Formula	C18H19N3O3S
Molecular Weight	357.43
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Rosiglitazone-d3 Rosiglitazone-d3 MedChemExpress (MCE) HY-17386S 1132641-22-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Rosiglitazone-d3 Rosiglitazone-d3 MedChemExpress (MCE) HY-17386S 1132641-22-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 μM) and an inhibitor of TRPM3[1][2][3][4]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Lehmann JM, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2 270(22):12953-6. [Content Brief] [3]. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996 Feb 2 39(3):665-8. [Content Brief] [4]. Thouennon E, et al. Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J Neurochem. 2015 Aug 134(3):463-70. [Content Brief] [5]. Majeed Y, et al. Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Mol Pharmacol. 2011 Jun 79(6):1023-30. [Content Brief] [6]. Ateyya H, et al. Beneficial effects of rosiglitazone and losartan combination in diabetic rats. Can J Physiol Pharmacol. 2018 Mar 96(3):215-220. [Content Brief]
Supplier Website	https://www.medchemexpress.com/rosiglitazone-d3.html
Last Update	2025-05-21 16:50:25

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