Acyclovir-d4 MedChemExpress (MCE)

Product Name	Acyclovir-d4
Synonyms	Zyclir-d4;Zovirax-d4;Cargosil-d4;Gerpevir-d4;Herpevir-d4;ACYCLOVIR-D4;Acyclovir-d4;Acicloftal-d4;2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy-d4)methyl]-6H-Purin-6-one
CAS	1185179-33-2
EINECS
Chemical Formula	C8H7D4N5O3
Molecular Weight	229.23
inchi
Package	1 mg
Price	Email to quote
Descriptions	Acyclovir-d4 Acyclovir-d4 MedChemExpress (MCE) HY-17422S1 1185179-33-2 Aciclovir-d4 Descriptions Acyclovir-d4 Acyclovir-d4 MedChemExpress (MCE) HY-17422S1 1185179-33-2 Aciclovir-d4 Acycloguanosine-d4 98.66% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Li Z, et al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep 10(5):251-7. [Content Brief] [3]. Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov 72(2):157-61. [Content Brief] [4]. Benedetti S, et al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15 215:80-85. [Content Brief] [5]. Hayashi K, et al. The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J Gene Med. 2006 Aug 8(8):1056-67. [Content Brief] [6]. Lönnqvist B, et al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May 1(3):139-44. [Content Brief]
Supplier Website	https://www.medchemexpress.com/acyclovir-d4.html
Last Update	2025-05-21 16:50:25

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