Sulfasalazine-d4 MedChemExpress (MCE)

Product Name	Sulfasalazine-d4
Synonyms	Azopyrin-d4 Azopyrine-d4 Azulfidine-d4 Azulfidine EN-d4 Sulfasalazine-d4 5-[p-(2-PyridylsulfaMyl-d4)phenylazo]salicylic Acid 5-[[p-(2-PyridylsulfaMoyl-d4)phenyl]azo]salicylic Acid Synonyms Azopyrin-d4 Azopyrine-d4 Azulfidine-d4 Azulfidine EN-d4 Sulfasalazine-d4 5-[p-(2-PyridylsulfaMyl-d4)phenylazo]salicylic Acid 5-[[p-(2-PyridylsulfaMoyl-d4)phenyl]azo]salicylic Acid 2-Hydroxy-5-[[4-[(2-pyridinylaMino-d4)sulfonyl]phenyl]azo]benzoic Acid
CAS	1346606-50-5
EINECS
Chemical Formula	C18H14N4O5S
Molecular Weight	398.39256
inchi
Package	1 mg
Price	Email to quote
Descriptions	Sulfasalazine-d4 Sulfasalazine-d4 MedChemExpress (MCE) HY-14655S 1346606-50-5 99.28% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Sulfasalazine-d4 Sulfasalazine-d4 MedChemExpress (MCE) HY-14655S 1346606-50-5 99.28% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Sulfasalazine-d4 is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Wahl C, et al. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest. 1998 Mar 1 101(5):1163-74. [Content Brief] [3]. Sykes L, et al. Sulfasalazine augments a pro-inflammatory response in interleukin-1β-stimulated amniocytes and myocytes. Immunology. 2015 Dec 146(4):630-44. [Content Brief] [4]. Chung WJ, et al. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. J Neurochem. 2009 Jul 110(1):182-93. [Content Brief] [5]. Mao C, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021 593(7860):586-590. [Content Brief]
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Last Update	2025-05-21 16:50:25

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