Topotecan-d6 MedChemExpress (MCE)

Product Name	Topotecan-d6
Synonyms	Hycamtin-d6 TOPOTECAN-D6 Topotecan-d6 NSC-609669-d6 SKF-104864A-d6 [2H6]-Topotecan (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Synonyms Hycamtin-d6 TOPOTECAN-D6 Topotecan-d6 NSC-609669-d6 SKF-104864A-d6 [2H6]-Topotecan (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4',6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS	1044904-10-0
EINECS
Chemical Formula	C23H23N3O5
Molecular Weight	421.45
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Topotecan-d6 Topotecan-d6 MedChemExpress (MCE) HY-13768S1 1044904-10-0 Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Topotecan-d6 Topotecan-d6 MedChemExpress (MCE) HY-13768S1 1044904-10-0 Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Topotecan-d6 is the deuterium labeled Topotecan. Topotecan (SKF 104864A NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87[1][2]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Zhang FL, et al. PLoS One. 2013 Nov 26 8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [Content Brief] [3]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1 17(17):5656-67. [Content Brief]
Supplier Website	https://www.medchemexpress.com/topotecan-d6.html
Last Update	2025-05-21 16:50:25

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